![]() These results also indicate that caution should be exercised when using SSD clinically to prevent or treat wound infections. Silvadene cream ( silver sulfadiazine) is a prescription treatment that is applied to skin wounds and severe burns. The results of this study demonstrate that SSD treatment contributes not only to impaired reepithelialization but also to a greater hypertrophic scar formation. At POD 28, when compared to the base cream-treated group (1.44 ± 0.03), SSD-treated-groups (0.1 and 1%) had more (P <. In contrast, analysis of granulation areas that represent volume of granulation tissue formed during healing did not show any statistical differences between the base cream-treated group and all three SSD-treated groups. A&D Original Ointment, Bag Balm, plain diaper rash ointment, silvadene cream, calendula lotion or ointment, or Balmex or Desitin ointment Used to topically treat minor sores and irritation. Epithelial gaps in SSD-treated groups at concentrations of 0.1 and 1% were significantly larger than those of base cream-treated controls. Treatment of blue fur disease may be performed with enrofloxacin dose of 5-10 mg / kg daily for 5-7 days and / or topical silver sulfadiazine cream. Silver sulfadiazine cream is used to prevent and treat wound infections in patients with second- and third-degree burns. At POD 28, the remaining rabbits from each group were assessed for hypertrophic scarring. Silver sulfadiazine cream (Silvadene, Marion) Topical q24h 82: Does not cause diarrhea if ingested: Sulfadimethoxine: 10-15 mg/kg PO q12h 62 : Sulfamethazine: 1 mg/mL drinking water 22 : 5-10 g/kg feed 22 : Sulfaquinoxaline: 1 mg/mL drinking water 22 : 0. At POD 7, half of the rabbits from each group were killed and tissues were harvested to measure wound healing parameters that included epithelial gap and granulation area. ![]() Each treatment was applied at 2-day intervals from postoperative days (PODs) 2 to 14. Twenty-four rabbits were randomized into four groups in which each group received base cream, 0.01% SSD, 0.1% SSD, or 1% SSD, respectively. Seven millimeter full-thickness excisional wounds were created in rabbit ears. Cream, External: Silvadene: 1 (20 g, 25 g, 50 g, 85 g, 400 g, 1000 g) contains methylparaben, propylene glycol SSD: 1 (25 g, 50 g, 85 g, 400 g) contains cetyl alcohol, methylparaben, propylene glycol Generic: 1 (20 g, 25 g, 50 g, 85 g, 400 g) Pharmacology Mechanism of Action. The cream should be applied once to twice daily to a thickness of approximately 1/16 inch. The burn areas should be covered with SILVADENE Cream 1 at all times. This study evaluated the effects of topical use of silver sulfadiazine cream (SSD) on wound healing and subsequent scarring in a rabbit ear wound model. The burn wounds are then cleansed and debrided, and SILVADENE Cream 1 (silver sulfadiazine) is applied under sterile conditions.
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